# UPDATE: ANTIBIOTIC RESISTANCE TRAJECTORIES Following our report yesterday on WHO's alarming antibiotic resistance estimates, new data from the CDC confirms that untreatable infections now cost the U.S. healthcare system approximately $4.6 billion annually in excess treatment expenses—a figure that has nearly doubled since 2015. This acceleration underscores why the WHO's projection of 10 million annual deaths by 2050 from resistant pathogens represents a conservative estimate rather than worst-case scenario, given current prescribing patterns in both hospital and agricultural settings remain largely unchanged across most developing nations.