HEALTH: Antibiotic Resistance Trajectory Antibiotic resistance kills approximately 1.27 million people annually, exceeding deaths from HIV/AIDS, and projections estimate 10 million annual deaths by 2050 if current trends continue—surpassing cancer mortality. The overuse of antibiotics in livestock accounts for 70% of antibiotic consumption in the US and EU, creating selection pressure for resistant bacteria that cross into human populations through food chains and environmental contamination. Methicillin-resistant Staphylococcus aureus (MRSA) emerged in hospitals in the 1960s within two years of methicillin's introduction, establishing a pattern: pathogens evolve resistance faster than pharmaceutical development cycles produce new drugs. This matters because we face a return to pre-antibiotic mortality rates for routine infections—surgical complications, childbirth, and minor wounds becoming life-threatening again—unless agricultural antibiotic use is restricted and new antimicrobial development is economically incentivized.